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Current treatment strategy of acute promyelocytic leukemia
Jianqing Mi
《医学前沿(英文)》 2011年 第5卷 第4期 页码 341-347 doi: 10.1007/s11684-011-0169-z
关键词:
acute promyelocytic leukemia
all-
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 45-52 doi: 10.1007/s11684-011-0117-y
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia. In past decades, intensive studies on the biology and treatment of this disease have resulted in a remarkably thorough understanding of its pathogenesis and improvement of treatment outcomes. In particular, the introduction of all-trans retinoic acid to conventional chemotherapy improved dramatically the remission and survival rates of APL patients and consequently became the major treatment modality for it. In the last decade, the groundbreaking development of arsenic further improved the survival rate of APL patients. As the most active agent in APL, arsenic directly degrades the PML-RARα fusion transcript, leading to the differentiation and apoptosis of leukemia cells and the potential eradication of APL leukemia-initiating cells (LICs), thus making the disease a potentially curable type of leukemia. More notably, the recent development of oral arsenic compounds may further enhance not only clinical outcomes but also the convenience of patients, which may dramatically change the APL clinical scenario in the near future.
关键词: acute promyelocytic leukemia arsenic all-trans retinoic acid survival
Selective pseudosolubilization capability of
Fei HUA, Hongqi WANG
《环境科学与工程前沿(英文)》 2013年 第7卷 第4期 页码 539-551 doi: 10.1007/s11783-013-0498-z
关键词:
Prayoga SURYADARMA, Yoshihiro OJIMA, Yuto FUKUDA, Naohiro AKAMATSU, Masahito TAYA
《化学科学与工程前沿(英文)》 2012年 第6卷 第2期 页码 152-157 doi: 10.1007/s11705-012-1287-0
关键词:
Synthesis of depsipeptides from
Hongfei CAO, Yakai FENG, Heyun WANG, Li ZHANG, Musammir KHAN, Jintang GUO
《化学科学与工程前沿(英文)》 2011年 第5卷 第4期 页码 409-415 doi: 10.1007/s11705-011-1141-9
关键词:
Assessment of toxicity of two nitroaromatic compounds in the freshwater fish
Hongyan SHEN, Jixi GAO, Jinsheng WANG
《环境科学与工程前沿(英文)》 2012年 第6卷 第4期 页码 518-523 doi: 10.1007/s11783-012-0427-6
关键词:
joint toxicity
A study on rapid acid chrome black (MB 7) spectrophotometric determination of ClO
Jing DONG, Huilong WANG
《化学科学与工程前沿(英文)》 2011年 第5卷 第2期 页码 245-251 doi: 10.1007/s11705-010-1003-x
关键词:
chlorine dioxide
2
6-dinitro-
Investigations on color variations of <italic>Morpho rhetenoritalic> butterfly wing scales
Guanglan LIAO, Haibo ZUO, Xuan JIANG, Xuefeng YANG, Tielin SHI
《机械工程前沿(英文)》 2012年 第7卷 第4期 页码 394-400 doi: 10.1007/s11465-012-0347-y
Experiments and simulations are carried out to investigate the optical properties of butterfly wing scales. The upper surface of a male butterfly wing presents a single-layer of scales, the microstructures of which are responsible for the brilliant blue color. The color varies from cyan blue to yellow green and soon afterwards returns back to cyan blue when some ethanol is dropped on the upper surface. At the start of the ethanol volatilization process, the reflection spectrum remains stable. As the ethanol further volatilizes, the peak reflectance decreases slightly, then increases dramatically. Meanwhile, the peak wavelength keeps approximately constant, then decreases, and keeps almost stable at the end of the process. Therefore, the optical properties depend strongly on the varying ambient conditions, including the refractive index and the thickness of the packing medium. Moreover, the possible causes for the scales in dark green region after several dropping ethanol experiments are clarified. This research benefits our understanding of the color variation mechanisms of the wing scales, and provides inspiration for further studies and applications.
关键词:
Wenzhen LI, Yu DING, Qian SUI, Shuguang LU, Zhaofu QIU, Kuangfei LIN
《环境科学与工程前沿(英文)》 2012年 第6卷 第4期 页码 445-454 doi: 10.1007/s11783-012-0419-6
关键词:
clofibric acid
advanced oxidation processes
intermediates
toxicity
Qi RUI, Qin LU, Dayong WANG
《医学前沿(英文)》 2009年 第3卷 第1期 页码 76-90 doi: 10.1007/s11684-009-0002-0
关键词:
Mutagenesis and selective breeding of a high producing
Tian WANG, Shiru JIA, Zhilei TAN, Yujie DAI, Shuai SONG, Guoliang WANG
《化学科学与工程前沿(英文)》 2012年 第6卷 第2期 页码 179-183 doi: 10.1007/s11705-012-1273-6
关键词:
Fengyu ZAN, Shouliang HUO, Beidou XI, Xiulan ZHAO
《环境科学与工程前沿(英文)》 2012年 第6卷 第1期 页码 51-58 doi: 10.1007/s11783-011-0206-9
关键词:
Kuiyi YOU, Fangfang ZHAO, Xueyan LONG, Pingle LIU, Qiuhong AI, Hean LUO
《化学科学与工程前沿(英文)》 2012年 第6卷 第4期 页码 389-394 doi: 10.1007/s11705-012-1218-0
关键词:
cyclohexane
One-pot three-component Mannich reaction catalyzed by sucrose char sulfonic acid
Qiong XU, Zhigao YANG, Dulin YIN, Jihui WANG
《化学科学与工程前沿(英文)》 2009年 第3卷 第2期 页码 201-205 doi: 10.1007/s11705-009-0052-5
关键词:
One–pot synthesis
What can be taught in architectural design? —
Xing RUAN
《结构与土木工程前沿(英文)》 2010年 第4卷 第4期 页码 450-455 doi: 10.1007/s11709-010-0098-y
标题 作者 时间 类型 操作
Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research direction
null
期刊论文
The <italic>rpoSitalic> deficiency suppresses acetate accumulation in glucose-enriched culture of <italic>Escherichia coliitalic> under an aerobic condition
Prayoga SURYADARMA, Yoshihiro OJIMA, Yuto FUKUDA, Naohiro AKAMATSU, Masahito TAYA
期刊论文
Synthesis of depsipeptides from
Hongfei CAO, Yakai FENG, Heyun WANG, Li ZHANG, Musammir KHAN, Jintang GUO
期刊论文
Assessment of toxicity of two nitroaromatic compounds in the freshwater fish
Hongyan SHEN, Jixi GAO, Jinsheng WANG
期刊论文
A study on rapid acid chrome black (MB 7) spectrophotometric determination of ClO
Jing DONG, Huilong WANG
期刊论文
Investigations on color variations of <italic>Morpho rhetenoritalic> butterfly wing scales
Guanglan LIAO, Haibo ZUO, Xuan JIANG, Xuefeng YANG, Tielin SHI
期刊论文
Identification and ecotoxicity assessment of intermediates generated during the degradation of clofibric acid
Wenzhen LI, Yu DING, Qian SUI, Shuguang LU, Zhaofu QIU, Kuangfei LIN
期刊论文
Mutagenesis and selective breeding of a high producing
Tian WANG, Shiru JIA, Zhilei TAN, Yujie DAI, Shuai SONG, Guoliang WANG
期刊论文
One-pot three-component Mannich reaction catalyzed by sucrose char sulfonic acid
Qiong XU, Zhigao YANG, Dulin YIN, Jihui WANG
期刊论文